Solid Phase Extraction (SPE) upstream of Liquid chromatography-mass spectrometry (LC-MS) is time-consuming, and complex, and is considered a significant “bottleneck” in the LC-MS bioanalytical workflow. Implementing fully automated SPE sample preparation greatly simplifies the analytical workflow, reduces human error, and improves analytical methods while freeing up the analyst to do other tasks.

This application note demonstrates the capabilities and flexibility of the Andrew+ Pipetting Robot in combination with the Extraction+ Connected Device, controlled by OneLab™ Software, for fully automated Solid Phase Extraction (SPE) sample preparation in cartridge and plate SPE formats.

Benefits of this automated solution include:

• Elimination of user interference
• Compatibility with SPE places and cartridge formats
• Liquid transfer flexibility into collection plates, tubes, and bottles
• Fully programmable vacuum pressure
• Automated sample prep efficiency and increased throughput